In 1976, professor ho wang lee discovered an antigen in the lung and kidney tissues of apodemus agrarius. Surveillance and outbreak reports a fiveyear perspective on the situation of haemorrhagic fever with renal syndrome and status of the hantavirus reservoirs in europe, 20052010 p heyman paul. In six patients the clinical presentation was suggestive of hfrs, as they had fever with. In europe, hemorrhagic fever with renal failure syndrome is caused by 3 hantaviruses. Viral hemorrhagic fever an overview sciencedirect topics. Hantaan virus was first discovered in 1976 by professor ho wang lee of the school of medicine at korea university. Hemorrhagic fever with renal syndrome in korea clinical. Hemorrhagic fever with renal syndrome pathology britannica.
A dry cough, sometimes accompanied by a few scattered rales on auscultation, is common, but prominent pulmonary symptoms are uncommon early in the course of the disease, except with hantavirus pulmonary syndrome. Hantavirus hemorrhagic fever with renal syndrome hfrs is a group of clinically similar illnesses caused by species of hantaviruses from the family hantaviridae, in the order bunyavirales. Hantavirus rna in saliva from patients with hemorrhagic. Epidemiological studies on hemorrhagic fever with renal. Fever, especially low grade fever is commonly seen among patients with severe kidney damage. Definition of hemorrhagic fever with renal syndrome. Pdf hemorrhagic fever with renal syndrome, zibo city. Sera from 609 hospitalized patients, from all six republics bosnia and hercegovina, croatia, macedonia, montenegro serbia, slovenia and two provinces kosovo and vojvodina, who had signs and symptoms suggestive of hfrs, and sera and lung tissues from 544 small mammals.
Hemorrhagic fever with renal syndrome caused by 2 lineages of dobrava. Although predominantly associated with rural areas, it is now being recognized as an urban problem in some countries, and also presents a particular hazard to laboratory staff who use rodents for biomedical research. Dobrava, hantaan, puumala, saaremaa, or seoul virus. A set of diseases, also known as hemorrhagic fever, characterized by the abrupt onset of high fever and chills, headache, cold and cough, and pain in the muscles, joints and abdomen with nausea and vomiting followed by bleeding into the kidney and elsewhere.
Hantavirus has been isolated from wild rats in baltimore and several other cities in the united states. Hemorrhagic fever with renal syndrome, russia pdf 1. Epidemiology of hemorrhagic fever with renal syndrome in endemic area of the republic of korea, 19951998 we conducted an epidemiologic study to understand temporal and spatial patterns of hemorrhagic fever with renal syndrome hfrs in the republic of korea rok. Epidemiology of hemorrhagic fever with renal syndrome in. Definition of fever with renal syndrome, hemorrhagic. The main natural reservoir of hantaviruses are murid rodents. Dec 27, 2018 fever with renal syndrome, hemorrhagic. Research hantavirus rna in saliva from patients with. The national notifiable disease surveillance system nndss was established online by china cdc in 2004 and rodent surveillance sites were adjusted to 40 sites in 22 provinces in 2005. Epidemiology and pathogenesis of hemorrhagic fever with renal. In this study, we evaluated the correlation between air pollution and hfrs incidence from. A viral hemorrhagic fever is a possible cause of the plague of athens during the peloponnesian war. Recently, 2 novel hantaviruses, with unknown pathogenic potential, were found in. With persistent research, six types of hantaviruses have been discovered in korea.
Hemorrhagic fever with renal syndrome is caused by distinct virus species pertaining to the family of bunyaviridae. Outbreak of acute illness southwestern united states, 1993 preliminary trials of inactivated vaccine against haemorrhagic fever with renal syndrome. Hfrs mainly distributes in asian and european countries 5. The major clinical manifestation was fever and all patients subsequently developed decreased renal function and proteinuria. During an outbreak of hemorrhagic fever with renal syndrome in the anhui province of china, a doortodoor survey was conducted of all of the 10,024 residents of eight village communities. Viral hemorrhagic fevers chapter 4 2020 yellow book.
Hemorrhagic fever with renal syndrome hfrs is a group of clinically similar illnesses caused by species of hantaviruses from the family hantaviridae. Analysis of hemorrhagic fever with renal syndrome cases in zibo city, china, during 20062014 showed that it occurred yearround. Haemorrhagic fever with renal syndrome in singapore. Hemorrhagic fever with renal syndrome hfrs is a disease which has not gained widespread recognition among clinicians in the united states, but which is, in fact, of considerable significance in many parts of the world. Sera from 609 hospitalized patients, from all six republics bosnia and hercegovina, croatia. We investigated to describe the extent of the outbreak and identify risk factors for infection. Pdf outbreak of haemorrhagic fever with renal syndrome. Hantaan virus 1976, seoul virus 1982, soocheong virus 2006, muju virus 2007, imjin virus 2009, and jeju virus 2012. Only a few such cases have been reported in the literature. What can a stage 4 kidney disease patient use for relieving fever. Hemorrhagic fever with renal failure syndrome clinical. Hemorrhagic fever with renal syndrome hfrs hantavirus cdc. Hantavirus hemorrhagic fever with renal syndrome hfrs is a group of clinically similar.
Pdf acute kidney injury occurs in 3350% of patients with rhabdomyolysis and infections remain one of the major contributing factors. Despite the high incidence of dengue fever, rhabdomyolysis leading to acute renal failure is an extremely rare complication of dengue fever. Hemorrhagic fever with renal syndrome hfrs is a rodentborne zoonosis caused by different species of hantaviruses, characterized by varying degrees of bleeding diathesis, hypertension, and renal failure. Clinical characterization of two severe cases of hemorrhagic. Emerging infectious diseases centers for disease control. The mechanisms that lead to the broad variance of severity in infected patients are not completely understood. Mar 19, 2010 hemorrhagic fever with renal syndrome department of infectious diseases third affiliated hospital of sun yatsen university lin yang slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Apr 12, 2020 a 57yearold woman was admitted to chonnam national university hospital, south korea, with fatigue, generalized myalgia, and nausea of 2 weeks duration. Although hfrs is associated primarily with rural areas, it is now being recognized as an urban problem and a particular hazard to laboratory staff. Early symptoms of hps include fever, muscle aches, fatigue, headaches, dizziness, chills, and abdominal problems. Rattus norvegicus is the natural host for the seoul hantavirus, causing hemorrhagic fever with renal syndrome hfrs in humans. Asia in asia, clinical cases of hfrs caused by htnv and seoul virus seov have been identified mainly in china, the republic of korea, and the far. Bat sarslike coronavirus wiv1 bat slcovwiv1, also sometimes called sarslike coronavirus wiv1, is a strain of severe acute respiratory syndrome related coronavirus sarsrcov isolated from chinese rufous horseshoe bats rhinolophus sinicus.
Viral hemorrhagic fever has sometimes been mistaken for acute appendicitis chapter 144 or other abdominal emergencies. Hemorrhagic fever with renal failure syndrome is caused by an airborne contact with secretions from rodent hosts infected with the group of viruses belonging to the g. Patients with haemorrhagic fever with renal syndrome hfrs may present without significant oliguria. Pdf hemorrhagic fever with renal syndrome complicated by. Hemorrhagic fever with renal failure syndrome is caused by an airborne contact with secretions from rodent hosts infected with the group of viruses belonging to the genus hantavirus of the family bunyaviridae. The clinical manifestations of hfrs are fever, hemorrhage and varying degrees of renal and hepatic dysfunction.
The hallmark of hfrs is the triad of fever, hemorrhage, and renal failure. It is also known as korean hemorrhagic fever, epidemic hemorrhagic fever, and nephropathia epidemica. Hantaan virus htnv causes hemorrhagic fever with renal syndrome hfrs, which is a zoonosis endemic in eastern asia, especially in china. Hfrs from dobrava virus dobv is a seldom reported disease in albania. Known also as hemorrhagic fever with renal syndrome. Prevention measures and communication strategies for. Several clinical variants of hemorrhagic fever with renal syndrome hfrs are caused by hantaan and related viruses. In 2017 zagreb faced the largest outbreak of haemorrhagic fever with renal syndrome hfrs to date.
An argentine physician named arribalzaga first recognized argentine hemorrhagic fever ahf in the early 1950s arribalzaga, 1955. Hemorrhagic fever with renal syndrome article about. Rodent infestation in and around the home remains the primary risk for hantavirus exposure. The aim of the present study was to analyze an outbreak of hemorrhagic fever with renal syndrome hfrs, caused by a hantavirus, in college students in the northern urban area of xian in 2012. Hemorrhagic fever with renal syndrome hfrs has been reported from 20 provinces in china. Epidemiological studies of hemorrhagic fever with renal. However, little is known about the effect of air pollution on the occurrence of hemorrhagic fever with renal syndrome hfrs, a rodentborne infectious disease. Epidemiology and pathogenesis of hemorrhagic fever with. Cdc assisted health officials in investigating an outbreak of seoul virus infection. During an outbreak in northern sweden of nephropathia epidemica ne, a milder form of hemorrhagic fever with renal syndrome, we collected saliva and plasma from 14 hospitalized ne patients with veri. Hantavirus hemorrhagic fever with renal syndrome wisconsin. A nationwide epidemic of hemorrhagic fever with renal syndrome hfrs occurred in yugoslavia in 1989.
There are major geographical differences in prevalence and severity, with the disease being a major public health concern in east asia. Epidemiological analysis of hemorrhagic fever with renal. Clinical and laboratory findings in patients with oliguric. Hemorrhagic fever with renal syndrome definition of. Hantaviruses causes two distinct clinical syndromes in humans. Acute renal impairment in coronavirusassociated severe. An outbreak of eight cases of haemorrhagic fever with renal syndrome in northwest greece is presented. Pdf hemorrhagic fever with renal syndrome in yugoslavia. Looking for online definition of hemorrhagic fever with renal syndrome in the medical dictionary. International notes hemorrhagic fever with renal syndrome france. Hantaviruses may cause hantavirus pulmonary syndrome hps, hemorrhagic fever with renal syndrome hfrs.
Hantavirus hemorrhagic fever with renal syndrome wikipedia. A number of diseases, also known as hemorrhagic fever, characterized by an abrupt onset of high fever and chills, headache, cold and cough, and pain in the muscles, joints and abdomen with nausea and vomiting followed by bleeding into the kidney and elsewhere. The national notifiable disease surveillance system nndss was established online by china cdc in 2004 and rodent surveillance sites were adjusted to 40 sites in. Peaks in spring and fallwinter were caused by hantaan and seoul viruses, respectively.
Oct 04, 2018 hemorrhagic fever with renal failure syndrome hfrs occurs mainly in europe and asia and is characterized by fever and renal failure associated with hemorrhagic manifestations. Dec 27, 2018 hemorrhagic fever with renal syndrome. The viruses that cause hps are present in the new world. Hantavirus pulmonary syndrome hps is a severe, sometimes fatal, respiratory disease in humans caused by infection with hantaviruses. Many arboviruses including those in the families togaviridae, flaviviridae, filoviridae, and bunyaviridae and the hantaviruses, spread by rodents or biting insects, can cause epidemic hemorrhagic fever.
Hemorrhagic fever with renal syndrome hfrs is a rodentborne disease caused by hantaviruses, which is primarily characterized by fever, circulatory collapse with hypotension, hemorrhage and acute kidney injury 4. Hemorrhagic fever with renal syndrome hfrs is a disease caused by viruses of the family bunyaviridae, genus hantavirus. Hemorrhagic fever with renal syndrome hfrs, also known as epidemic hemorrhagic fever, which is also referred to as epidemic hemorrhagic fever. Hantavirus pulmonary syndrome outbreak in yosemite park ecdc. Outbreak of haemorrhagic fever with renal syndrome in. The species that cause hfrs include hantaan, dobravabelgrade, saaremaa, seoul, and puumala. Meteorological factors and risk of hemorrhagic fever with. The outbreak of deadly hantavirus pulmonary syndrome hps in the united states in 1993 cdc. Clinical characteristics of haemorrhagic fever with renal. The initial cases occurred in agricultural workers near the town of junin. Genetic investigation of novel hantaviruses causing fatal. The disease was diagnosed by rising antibody titers to the hantaan virus. Haemorrhagic fever with renal syndrome definition of. View abstract cite this article email this article in russia, 1,590 cases of hemorrhagic fever with renal syndrome caused by 6 different hantaviruses were reported during 20002017.
This syndrome is caused by a newly recognized genus of viruses, the genus. A person with stage 4 kidney disease is more likely to suffer from more serious conditions due to severe decline of renal function. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Air pollution and hemorrhagic fever with renal syndrome in. The clinical picture and severity of infections differ between hantavirus species and may even vary between hantavirus genotypes. Epidemiologic and epizootiologic features of a nationwide outbreak in 1989. The outbreak affected six students and included two deaths. To determine causative agents, we examined 126 cases of dobvassociated hfrs in central and southern european russia. Epidemic characteristics of hemorrhagic fever with renal. In the 1990s, an outbreak of hfrs in 2 regions of european russia tula and. Apr 15, 20 the effects of air pollution on the respiratory and cardiovascular systems, and the resulting impacts on public health, have been widely studied. Haemorrhagic fever with renal syndrome hfrs, a rodentborne infectious disease caused by hantaviruses, is clinically characterized in humans by fever, haemorrhage, headache, abdominal pain, and acute kidney damage. The viruses that cause both hps and hfrs are transmitted to humans through contact with urine, feces, or saliva of infected rodents.
Recent puuv outbreaks raised questions concerning increasing frequency of. A fiveyear perspective on the situation of haemorrhagic. Wholegenome sequences of htnv from hfrs patients and lung tissues of seropositive apodemus agrarius were obtained by multiplex polymerase chain reactionbased. Hantaviruses cause hantavirus pulmonary syndrome hps and hemorrhagic fever with renal syndrome hfrs. Hemorrhagic fever with renal centers for disease control.
It is also known as korean hemorrhagic fever and epidemic hemorrhagic fever. Causes of fever in dialysis patients and its treatment. Hemorrhagic fever with renal syndrome caused by 2 lineages. The viruses that cause hfrs include hantaan, dobrava, saaremaa, seoul, and puumala. Hantaan virus htnv, seoulvirus seov, puumalavirus puuv and dobrava virus dobv 2,3.
During an outbreak in northern sweden of nephropathia epidemica ne, a milder form of hemorrhagic fever with renal syndrome, we collected saliva and plasma from 14 hospitalized ne patients with verified puumala virus puuv infection. However, what can patients use for relieving fever. Peaks in spring and fallwinter were caused by hantaan and seoul. Creative commons attribution license ccby for citation purposes. A vhf outbreak in the village of mweka, democratic republic of the congo drc that started in august 2007, and that has killed 103 people 100 adults and three children, has been shown to be caused at least partially by ebola virus. Laboratory rat associated outbreak of haemorrhagic fever with renal syndrome due to hantaanlike virus in belgium. In france, the first two autochthonous cases of hemorrhagic fever with renal syndrome hfrs were recognized in november 1982 and june 1983 1,2. Since 1951, 500900 patients with hfrs have been hospitalized annually in korea. Orthohantavirus is a genus of singlestranded, enveloped, negativesense rna viruses in the. One report cites evidence of human infection with a ratassociated hantavirus childs et al. The disease was diagnosed by rising antibody titers to. Hemorrhagic fever with renal syndrome hfrs is caused by hantaviruses in the asiapacific area. All of the cases reported before 1981 were from rural areas and were attributed to apodemus rats.
Other articles where hemorrhagic fever with renal syndrome is discussed. Hfrs mild, outbreaks confirmed in laboratories in the 1980s. Nov 14, 2016 hantavirus disease belongs to the emerging infections. Hemorrhagic fever with renal syndrome hfrs is a group of clinically similar. For this reason, we studied whether saliva from hfrs patients contained hantavirus. An outbreak of haemorrhagic fever with renal syndrome. Four us soldiers acquired hemorrhagic fever with renal syndrome while training near the demilitarized zone, south korea, in 2005. The main manifestation of hfrs, including acute kidney injury, increases vascular permeability, and coagulation abnormalities.
From january 1988 to september 1989, seven patients 4 girls and 3 boys, aged 312 years with haemorrhagic fever with renal syndrome hfrs were hospitalised at the university childrens hospital in belgrade. The number of reported cases has increased markedly in recent years and surpassed 80,000 human cases in 1983. Argentine hemorrhagic fever an overview sciencedirect topics. Hemorrhagic fever with renal syndrome hfrs is an acute viral disease that occurs over wide areas of europe and asia. Outbreaks of illnesses characterised by haemorrhagic fever associated with a renal syndrome were reported in the early. Highresolution phylogeographic analysis of hantaan orthohantavirus htnv s segment from hemorrhagic fever with renal syndrome hfrs outbreaks after active targeted surveillance. The ebola virus is a notorious cause of epidemic hemorrhagic fever. Pdf nonhemorrhagic dengue fever with rhabdomyolysis. The species that cause hfrs include hantaan orthohantavirus, dobravabelgrade orthohantavirus, saaremaa virus, seoul. Like all coronaviruses, virions consist of singlestranded positivesense rna enclosed within an envelope. Hemorrhagic fever with renal syndrome in yugoslavia.
Hfrs includes diseases such as korean hemorrhagic fever, epidemic hemorrhagic fever, and nephropathis epidemica. In its severeform it is associated with significant mortality. These illnesses typically develop within 1 to 2 weeks of exposure sometimes later and are characterized by acute fever, severe headache, blurred vision, and nausea. Hfrs includes diseases such as korean hemorrhagic fever, epidemic hemorrhagic fever, and nephropathia epidemica. Meaning of hemorrhagic fever with renal syndrome medical term.
Dobravabelgrade virus dobv is a european hantavirus that causes hemorrhagic fever with renal syndrome hfrs. Hemorrhagic fever with renal syndrome hfrs caused by hantaviruses is a serious public health problem in china. What does hemorrhagic fever with renal syndrome mean. The incidence rates were higher in males than in females and higher in adults than in children.
Anyone who comes into contact with rodents that carry hantaviruses is at risk of hps. The reservoir host of htnv is field mouse apodemus agraricus. International notes hemorrhagic fever with renal syndrome. Haemorrhagic fever with renal syndrome hfrs is a public health problem throughout most of the european and asian land mass. Review article hantavirus infection viral diseases enivd.
Explanation of hemorrhagic fever with renal syndrome. Mar 30, 2020 hemorrhagic fever with renal syndrome hfrs, which is caused by hantaan, puumala, seoul, and dobravabelgrade viruses htnv, puuv, seov, and dobv, respectively is acquired primarily through. Analysis of an outbreak of hemorrhagic fever with renal. We estimated the incidence among civilians in endemic areas through the active. Rodent hosts were the striped field mouse for hantaan virus and the brown rat and house mouse for seoul virus. Hemorrhagic fever with renal syndrome hfrs is a group of clinically similar illnesses caused by hantaviruses from the family bunyaviridae. Apart from fever and respiratory complications, acute renal impairment has been observed in some patients with sars. Hemorrhagic fever with renal syndrome, zibo city, china. Global geographic distribution of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. Find out information about hemorrhagic fever with renal syndrome. Asia in asia, clinical cases of hfrs caused by htnv and seoul virus seov have been identified mainly in china, the republic of korea, and the far east region of the russia federation table 1.
Dec 15, 2016 hemorrhagic fever with renal syndrome hfrs, also known as epidemic hemorrhagic fever, which is also referred to as epidemic hemorrhagic fever, is a kind of natural focal disease that is induced. Hemorrhagic fever with renal syndrome caused by 2 lineages of. Epidemiological investigations following an outbreak of hemorrhagic fever with renal syndrome in. Hantaviruses have the potential to cause two different types of diseases in human.
539 1503 558 361 1338 729 944 1055 343 1458 143 1005 60 388 536 1356 301 962 468 177 618 1168 88 209 826 627 341 1288 301 820 513 603 1140 583 1109 1246